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Group B streptococcal infection

MedGen UID:
378336
•Concept ID:
C2020625
•
Disease or Syndrome
Synonyms: Group B Strep Infection; Group B Streptococcal Infection; Group B Streptococcal Infections
SNOMED CT: Streptococcus agalactiae infection (426933007); Infection due to Streptococcus group B (426933007)
 
Monarch Initiative: MONDO:0700218

Definition

Group B Streptococcus, also known as Streptococcus agalactiae, colonizes the vaginal and gastrointestinal tracts of up to 45% of healthy women and may infect neonates in utero or during delivery, causing neonatal sepsis in 1-2% of colonized neonates. GBS infection may also occur in nonpregnant (particularly elderly) adults with underlying medical conditions, presenting as urinary tract infection, pneumonia, or soft-tissue infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGroup B streptococcal infection

Professional guidelines

PubMed

Progress in Diagnosis and Treatment of Neonatal Sepsis: A Review Article.
Yadav P, Yadav SK
JNMA J Nepal Med Assoc 2022 Mar 11;60(247):318-324. doi: 10.31729/jnma.7324. PMID: 35633256Free PMC Article
Perinatal Management of Group B Streptococcal Infection: Clinical Update.
Howard ED
J Perinat Neonatal Nurs 2019 Oct/Dec;33(4):280-282. doi: 10.1097/JPN.0000000000000445. PMID: 31651622
Group B streptococcal infection in older patients. Spectrum of disease and management strategies.
Farley MM
Drugs Aging 1995 Apr;6(4):293-300. doi: 10.2165/00002512-199506040-00004. PMID: 7613018

Curated

UK NICE Guideline NG195, Neonatal infection: antibiotics for prevention and treatment, 2021

Recent clinical studies

Etiology

Progress in Diagnosis and Treatment of Neonatal Sepsis: A Review Article.
Yadav P, Yadav SK
JNMA J Nepal Med Assoc 2022 Mar 11;60(247):318-324. doi: 10.31729/jnma.7324. PMID: 35633256Free PMC Article
Perinatal Management of Group B Streptococcal Infection: Clinical Update.
Howard ED
J Perinat Neonatal Nurs 2019 Oct/Dec;33(4):280-282. doi: 10.1097/JPN.0000000000000445. PMID: 31651622
Breast milk and Group B streptococcal infection: vector of transmission or vehicle for protection?
Le Doare K, Kampmann B
Vaccine 2014 May 30;32(26):3128-32. Epub 2014 Apr 13 doi: 10.1016/j.vaccine.2014.04.020. PMID: 24736004Free PMC Article
Neonatal infections: group B streptococcus.
Heath PT, Jardine LA
BMJ Clin Evid 2014 Feb 28;2014 PMID: 24580886Free PMC Article
Myth: Group B streptococcal infection in pregnancy: comprehended and conquered.
Steer PJ, Plumb J
Semin Fetal Neonatal Med 2011 Oct;16(5):254-8. Epub 2011 Apr 13 doi: 10.1016/j.siny.2011.03.005. PMID: 21493170

Diagnosis

Progress in Diagnosis and Treatment of Neonatal Sepsis: A Review Article.
Yadav P, Yadav SK
JNMA J Nepal Med Assoc 2022 Mar 11;60(247):318-324. doi: 10.31729/jnma.7324. PMID: 35633256Free PMC Article
Updates in prevention policies of early-onset group B streptococcal infection in newborns.
Zhu Y, Lin XZ
Pediatr Neonatol 2021 Sep;62(5):465-475. Epub 2021 May 23 doi: 10.1016/j.pedneo.2021.05.007. PMID: 34099416
Burden of Adults Hospitalized With Group B Streptococcal Infection.
McLaughlin JM, Peyrani P, Furmanek S, Khan FL, Quinn A, Jodar L, Ramirez J, Swerdlow DL
J Infect Dis 2021 Oct 13;224(7):1170-1178. doi: 10.1093/infdis/jiaa110. PMID: 32188975Free PMC Article
Myth: Group B streptococcal infection in pregnancy: comprehended and conquered.
Steer PJ, Plumb J
Semin Fetal Neonatal Med 2011 Oct;16(5):254-8. Epub 2011 Apr 13 doi: 10.1016/j.siny.2011.03.005. PMID: 21493170
Group B streptococcal infection in older patients. Spectrum of disease and management strategies.
Farley MM
Drugs Aging 1995 Apr;6(4):293-300. doi: 10.2165/00002512-199506040-00004. PMID: 7613018

Therapy

Effectiveness of intrapartum antibiotic prophylaxis for early-onset group B Streptococcal infection: An integrative review.
Braye K, Ferguson J, Davis D, Catling C, Monk A, Foureur M
Women Birth 2018 Aug;31(4):244-253. Epub 2017 Nov 10 doi: 10.1016/j.wombi.2017.10.012. PMID: 29129472
Breast milk and Group B streptococcal infection: vector of transmission or vehicle for protection?
Le Doare K, Kampmann B
Vaccine 2014 May 30;32(26):3128-32. Epub 2014 Apr 13 doi: 10.1016/j.vaccine.2014.04.020. PMID: 24736004Free PMC Article
Neonatal infections: group B streptococcus.
Heath PT, Jardine LA
BMJ Clin Evid 2014 Feb 28;2014 PMID: 24580886Free PMC Article
Myth: Group B streptococcal infection in pregnancy: comprehended and conquered.
Steer PJ, Plumb J
Semin Fetal Neonatal Med 2011 Oct;16(5):254-8. Epub 2011 Apr 13 doi: 10.1016/j.siny.2011.03.005. PMID: 21493170
Group B streptococcal infections.
McKenna DS, Iams JD
Semin Perinatol 1998 Aug;22(4):267-76. doi: 10.1016/s0146-0005(98)80015-3. PMID: 9738991

Prognosis

Neonatal Group B Streptococcal Infection in Australia: A Case-control Study.
Yanni M, Stark M, Francis L, Francis JR, McMillan M, Baird R, Heath PT, Gordon A, Riccardione J, Wilson A, Lee R, Chooi K, Quinn OP, Marshall HS
Pediatr Infect Dis J 2023 May 1;42(5):429-435. Epub 2023 Mar 16 doi: 10.1097/INF.0000000000003881. PMID: 36929884
Progress in Diagnosis and Treatment of Neonatal Sepsis: A Review Article.
Yadav P, Yadav SK
JNMA J Nepal Med Assoc 2022 Mar 11;60(247):318-324. doi: 10.31729/jnma.7324. PMID: 35633256Free PMC Article
Burden of Adults Hospitalized With Group B Streptococcal Infection.
McLaughlin JM, Peyrani P, Furmanek S, Khan FL, Quinn A, Jodar L, Ramirez J, Swerdlow DL
J Infect Dis 2021 Oct 13;224(7):1170-1178. doi: 10.1093/infdis/jiaa110. PMID: 32188975Free PMC Article
Group B streptococcal infection in Taiwan: maternal colonization and neonatal infection.
Yu HW, Lin HC, Yang PH, Hsu CH, Hsieh WS, Tsao LY, Chen CH, Lin HC, Tseng YC
Pediatr Neonatol 2011 Aug;52(4):190-5. Epub 2011 Jun 15 doi: 10.1016/j.pedneo.2011.05.008. PMID: 21835363
Neonatal infections: group B streptococcus.
Heath PT, Jardine LA
BMJ Clin Evid 2010 Sep 27;2010 PMID: 21418675Free PMC Article

Clinical prediction guides

Self-collection of samples for group B streptococcus testing during pregnancy: a systematic review and meta-analysis.
Borg SA, Cao J, Nguyen PY, Aziz S, Vogel JP
BMC Med 2023 Dec 18;21(1):498. doi: 10.1186/s12916-023-03186-x. PMID: 38110910Free PMC Article
Epidemiology of group B streptococcal infection in pregnant women and diseased infants in mainland China.
Huang J, Lin XZ, Zhu Y, Chen C
Pediatr Neonatol 2019 Oct;60(5):487-495. Epub 2019 Jul 26 doi: 10.1016/j.pedneo.2019.07.001. PMID: 31445795
Effectiveness of intrapartum antibiotic prophylaxis for early-onset group B Streptococcal infection: An integrative review.
Braye K, Ferguson J, Davis D, Catling C, Monk A, Foureur M
Women Birth 2018 Aug;31(4):244-253. Epub 2017 Nov 10 doi: 10.1016/j.wombi.2017.10.012. PMID: 29129472
Group B streptococcal infection and activation of human astrocytes.
Stoner TD, Weston TA, Trejo J, Doran KS
PLoS One 2015;10(6):e0128431. Epub 2015 Jun 1 doi: 10.1371/journal.pone.0128431. PMID: 26030618Free PMC Article
Neonatal infections: group B streptococcus.
Heath PT, Jardine LA
BMJ Clin Evid 2010 Sep 27;2010 PMID: 21418675Free PMC Article

Recent systematic reviews

Epidemiology of group B streptococcal infection in pregnant women and diseased infants in mainland China.
Huang J, Lin XZ, Zhu Y, Chen C
Pediatr Neonatol 2019 Oct;60(5):487-495. Epub 2019 Jul 26 doi: 10.1016/j.pedneo.2019.07.001. PMID: 31445795
Effectiveness of intrapartum antibiotic prophylaxis for early-onset group B Streptococcal infection: An integrative review.
Braye K, Ferguson J, Davis D, Catling C, Monk A, Foureur M
Women Birth 2018 Aug;31(4):244-253. Epub 2017 Nov 10 doi: 10.1016/j.wombi.2017.10.012. PMID: 29129472
Vaginal chlorhexidine during labour to prevent early-onset neonatal group B streptococcal infection.
Ohlsson A, Shah VS, Stade BC
Cochrane Database Syst Rev 2014 Dec 14;2014(12):CD003520. doi: 10.1002/14651858.CD003520.pub3. PMID: 25504106Free PMC Article
Neonatal infections: group B streptococcus.
Heath PT, Jardine LA
BMJ Clin Evid 2014 Feb 28;2014 PMID: 24580886Free PMC Article
Neonatal infections: group B streptococcus.
Heath PT, Jardine LA
BMJ Clin Evid 2010 Sep 27;2010 PMID: 21418675Free PMC Article

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    Curated

    • NICE, 2021
      UK NICE Guideline NG195, Neonatal infection: antibiotics for prevention and treatment, 2021

    Consumer resources

    Reviews

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